Today, the 36-year-old seems to be disrupting every paradigm he can find.
But his most ambitious project to date could be his attempt to disrupt another area of tech — cancer research.
The Parker Institute for Cancer Immunotherapy is a $250 million initiative to fight cancer by combining the powers of 300 scientists in 40 university labs.
And cancer isn't the only disease Parker wants to fight.
He's invested $24 million in Stanford University for allergy research, given $4.5 million to University of California San Francisco to fight malaria and put $1 million toward marijuana legalization in California — we can presume that's at least partly due to its reported medicinal benefits.
As for the cancer project, Parker has described its scientific model as a "virtual sandbox" where researchers can collaborate to fight cancer and other diseases.
Parker told CNBC: "The scientists, actually, they're the easiest part of this equation ... They want to share data. So this is kind of a grand experiment in how do we remove all the obstacles, the barriers that would prevent them from sharing data?"
Parker told The New York Times: "This is my primary philanthropic project, probably for the rest of my life."